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Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection
There are several lines of evidence that might support a role for vitamin D status in SARS-CoV-2 infection.
Firstly, vitamin D deficiency is a common condition all around the world, and serum 25-hydroxyvitamin D levels follow a well-known seasonal and geographical pattern.
Spain, located in temperate zones of the Northern Hemisphere, but with a higher prevalence of vitamin D deficiency, has reached very high rates of SARS-CoV-2 infection and lethality.
Secondly, vitamin D is a steroid hormone involved in the modulation of the innate and acquired immune system and also in the production of antimicrobial peptides, such as cathelicidin and human β-defensin-2, as well as in the expression of genes involved in the intracellular destruction of pathogens.
In this sense, vitamin D can inhibit proinflammatory cytokine production in human monocytes/macrophages, and chronic vitamin D deficiency may induce RAS activation, leading to the production of fibrotic factors and lung damage.
Taking into account the above considerations, we aimed to assess the serum 25OHD levels in hospitalised patients with COVID-19 compared with population-based controls.
The possible association between serum 25OHD concentrations and COVID-19 severity and mortality was also analysed.
Also remember that Covid-19, as such, has not been proven to exist. So what we are talking about are hospital patients who have Influenza A or B or even a severe cold, which could adversely affect those with underlying health conditions.
Read the full article here
Firstly, vitamin D deficiency is a common condition all around the world, and serum 25-hydroxyvitamin D levels follow a well-known seasonal and geographical pattern.
Spain, located in temperate zones of the Northern Hemisphere, but with a higher prevalence of vitamin D deficiency, has reached very high rates of SARS-CoV-2 infection and lethality.
Secondly, vitamin D is a steroid hormone involved in the modulation of the innate and acquired immune system and also in the production of antimicrobial peptides, such as cathelicidin and human β-defensin-2, as well as in the expression of genes involved in the intracellular destruction of pathogens.
In this sense, vitamin D can inhibit proinflammatory cytokine production in human monocytes/macrophages, and chronic vitamin D deficiency may induce RAS activation, leading to the production of fibrotic factors and lung damage.
Taking into account the above considerations, we aimed to assess the serum 25OHD levels in hospitalised patients with COVID-19 compared with population-based controls.
The possible association between serum 25OHD concentrations and COVID-19 severity and mortality was also analysed.
Also remember that Covid-19, as such, has not been proven to exist. So what we are talking about are hospital patients who have Influenza A or B or even a severe cold, which could adversely affect those with underlying health conditions.
Read the full article here